KMID : 1039920190260030155
|
|
Neonatal Medicine 2019 Volume.26 No. 3 p.155 ~ p.161
|
|
Effects of Early Phosphorus Intake on Respiratory Distress in Extremely Low-Birth-Weight Infants
|
|
Bae Hye-Jung
Yoon Hyung-Woo Kim Moon-Jin Jung Ae-Hee Jung Sun-Hoi Hahn Hyeon-Joo Jo Yun-Hee Cho Yoon-Sook Kim Ee-Kyung Shin Seung-Han Song In-Gyu Shin Seung-Hyun
|
|
Abstract
|
|
|
Purpose: This study was aimed to investigate the effect of early phosphorus intake on respiratory distress in extremely low-birth-weight infants (ELBWIs) with a high incidence of hypophosphatemia.
Methods: We performed a retrospective study to target 164 ELBWIs admitted to the neonatal intensive care unit in Seoul National University Children¡¯s Hospital. Birth characteristics, nutritional intake, and electrolyte levels during the first week were investigated as predictors that would affect the clinical outcomes. The correlations among invasive ventilation at postnatal age of 2 weeks, moderate-to-severe bronchopulmonary dysplasia (BPD), and phosphorous intake were analyzed.
Results: Hypophosphatemia (phosphorus level <4 mg/dL) was observed in 72.0% of the subjects. The rates of invasive ventilation (P=0.001) and moderate-to-severe BPD (P=0.005) were significantly lower in the high phosphorus intake group (¡Ã0.7 mM/kg/day) than in the low phosphorus intake group (<0.7 mM/kg/day). Phosphorus intake during the first week was a significant factor affecting invasive ventilation at 2 weeks of age (adjusted odds ratio [OR], 8.212; 95% confidence interval [CI], 2.256 to 28.896; P=0.001) and moderate-to-severe BPD (adjusted OR, 3.402; 95% CI, 1.274 to 9.084; P=0.015).
Conclusion: Early insufficient phosphorus intake confers a significantly higher risk with invasive ventilation at 2 weeks of age and moderate-to-severe BPD. Therefore, early sufficient phosphorus supply may improve respiratory outcomes in ELBWIs.
|
|
KEYWORD
|
|
Infant, extremely low birth weight, Phosphorus, Respiratory distress, Bronchopulmonary dysplasia
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|